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解惑“78m.ppt”-知识课堂

专家最新研究78m.ppt:应加强对2型糖尿病患者抑郁状态的监测、干预

来源: 搜狐新闻
2024-12-17 00:01:34

最佳回答

“78m.ppt”专家最新研究78m.ppt:应加强对2型糖尿病患者抑郁状态的监测、干预

  中新78m.ppt网上海12月16日电(孙国根 78m.ppt陈静)记者16日获悉,中国医学专家在中位数时长超过13年的追踪随访研究中揭示了抑郁与2型糖尿病并发症发病风险的关系。他们发现,抑郁组的全因死亡率是非抑郁组的1.26倍。

  复旦大学公共卫生学院余勇夫教授当日对记者表示,既往对2型糖尿病患者不良预后的防控策略往往集中在血糖监测和行为干预上,却忽略了精神健康因素的潜在威胁。

  复旦大学公共卫生学院徐望红教授、余勇夫教授与上海市肿瘤研究所屠红教授合作研究采用临床诊断和量表评估两种方法对2型糖尿病患者的抑郁状态进行评估。

  研究团队对多种潜在的混杂因素进行了调整(校准),结果显示,与非抑郁者(不管是临床78m.ppt抑郁还是抑郁症状)相比,2型糖尿病合并抑郁者发生大多数并发症的风险较高,包括心力衰竭、动脉粥样硬化型心血管疾病、冠状动脉疾病、综合性微血管并发症、糖尿病肾病、糖尿病神经性病变,为非抑郁者的1.17倍至1.96倍。

  研究团队方面介绍,抑郁常与糖尿病并发且经常伴有吸烟和缺乏运动等不健康行为。同时,合并抑郁的糖尿病人更容易出现自我护理能力差和血糖控制不佳的情况。这些原因都可能导致未来的血管功能障碍,从而使预后更差。

  该研究团队通过引入小分子代谢物,进一步发现了该通路涉及的潜在生物标志物。据悉,他们进一步探讨了一系列循环代谢物(共22种)在重度抑郁障碍与糖尿病血管并发症之间关系中的潜在中介效应。结果显示,血脂状况、肾功能和炎症相关的循环代谢物是该通路中的重要生物标志物。

  据悉,上述该研究相关论文已发表在最新一期国际学术期刊《柳叶刀》的子刊《临床医学》上。该研究对加强2型糖尿病患抑郁状态的监测、干预和降低糖尿病并发症的发病风险有重要意义。(完)

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