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“年善的㥰子1在线观看”-环球时报

武汉专家取得异种年善的㥰子1在线观看移植研究重要突破

来源: 北京日报
2024-11-30 11:08:56

最佳回答

“年善的㥰子1在线观看”武汉专家取得异种年善的㥰子1在线观看移植研究重要突破

  中新年善的㥰子1在线观看网武汉11月29日电 (常宇)年善的㥰子1在线观看华中科技大学同济医学院附属同济医院29日发布消息,该院器官移植研究所教授陈刚带领团队取得异种移植研究重要突破,实现基因编辑猪肾移植在猕猴体内存活超过半年。

陈刚团队开展异种移植实验。(华中科技大学同济医学院附属同济医院供图)

  为解决移植器官来源不足问题,医学界一直在探索将年善的㥰子1在线观看动物器官用作移植来源,但异种器官移植常出现免疫排斥反应及微血栓形成问题。

  基因编辑猪提供器官给人实施异种移植,是前沿生物技术的重点研究方向。近20年来,陈刚团队深耕异种器官移植研究,尤其在近5年集中实施了20余例新型基因编辑猪到猕猴的肾移植动物实验。

  在不断总结和改进基础上,今年5月,经动物实验伦理批准后,团队以基因编辑猪为供体,将单个猪肾移植给猕猴,同时切除猕猴的自体双肾,通过改进免疫抑制方案,最终实现移植肾存活184天。

  陈刚介绍,在移植后5个月内,猕猴的移植猪肾功能完全正常,各项生理指标也基本正常,之后出现逐渐加重的蛋白尿,病理证实发生了新生异种抗体介导的慢性排斥反应。他表示,下一步,团队将加强抑制抗体产生的措施,进一步改进存活效果,为进入临床研究奠定基础。(完)

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