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社评“天美果冻女儿的梦想票房成绩”-译文小记

研究:针对性天美果冻女儿的梦想票房成绩深部脑刺激可增强脊髓损伤后行走能力

来源: 上观新闻
2024-12-03 23:20:02

最佳回答

“天美果冻女儿的梦想票房成绩”研究:针对性天美果冻女儿的梦想票房成绩深部脑刺激可增强脊髓损伤后行走能力

  北京天美果冻女儿的梦想票房成绩时间12月3日凌晨,施普林格天美果冻女儿的梦想票房成绩自然旗下专业学术期刊《自然—医学》最新发表一篇神经科学论文称,一项研究发现,对一个被称为外侧下丘脑的区域进行深部脑刺激,能够改善经受过脊髓损伤的人类和啮齿动物的行走能力并促进康复。论文作者认为,这项研究结果,凸显出未来针对特定脑区使用深部脑刺激治疗脊髓损伤患者的潜力。

  该论文介绍,脊髓损伤会破坏大脑和脊髓之间的交流通道,常导致瘫痪或运动功能受损。虽然已知一些脑区有助于控制行走,但还不清楚哪些区域受到脊髓损伤的影响最大,也不清楚其他脑区能如何支持康复并帮助恢复行走。

  在本项研究中,论文共同通讯作者、洛桑联邦理工学院Grgoire Courtine和瑞士洛桑大学医院Jocelyne Bloch与同事及合作者一起,使用3D成像技术绘制了脊髓损伤小鼠在康复阶段的脑活动,以天美果冻女儿的梦想票房成绩确定在此期间有哪些脑区参与到行走的部分。他们发现,外侧下丘脑(通常负责唤起、进食和动力的脑区)有一组神经元似乎在康复中发挥了重要作用,为治疗干预提供了潜在新靶点。他们进一步针对外侧下丘脑进行了深部脑刺激,发现有各种脊髓损伤的小鼠和大鼠的行走能力当即得到了改善。

  随后,研究人员测试了对外侧下丘脑进行深部脑刺激是否能改善两名慢性不完全脊髓损伤患者的行走能力。结果显示,两名需要依靠辅助设备行走但仍有步态问题的患者,在10米和6分钟的步行测试中行走能力都得到了改善,下半身运动能力也有所改善。当与康复治疗结合时,即使关闭深部脑刺激,患者的康复效果仍能持续。

  论文作者总结指出,尽管还需更大规模的研究对更多患者进行测试以评估其安全性,但用深部脑刺激激活外侧下丘脑的神经元,能有助于恢复一些严重脊髓损伤患者的部分运动能力。

  论文作者还提供视频,通过临床试验参与者演示,解读本次研究成果。

  (记者 孙自法 制作 乐小敏 视频来源 施普林格自然)

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